Dr. Deng-Fu Guo

Dr. Deng-Fu Guo |Clyto Access

University of Iowa, USA

Editorial Board Member

Expertise: Obesity, Diabetes, Hypertension, Ciliopathy, Leptin & leptin receptor, Insulin & insulin resistance, G protein coupled receptors, Energy homeostasis, Energy expenditure, Renin angiotensin system, Metabolic regulation


Dr. Guo received his Ph.D. degree from Hokkaido University, Hokkaido, Japan on March 1991. He was post-doctoral fellow in Dr. Tadashi Inagami Laboratory at Department of Biochemistry, Vanderbilt University, Nashville, TN in 1991 to 1994.He then moved to Department of Medicine, University of Montreal, Montreal, Quebec, Canada in 1997 to 2007, continued to investigate physiological function of the receptor-associated proteins in vivo and in vitro.  In 2007, he moved back to the United State. Currently is a research scientist at Department of Pharmacology, University of Iowa, IA, and investigates molecular mechanisms of obesity and obese-associated hypertension using genetic mouse models mimicking human Bardet Biedl syndrome, aciliopathy. Particularly, his study focuses on central nervous system, hypothalamus, a key place regulating energy homeostasis. He and his colleagues demonstrated that BBS proteins play an important role for trafficking leptin receptor to the plasma membrane, and mutation of BBS proteins leads abnormal leptin receptor trafficking, resulting decreased leptin receptor signaling, which may be an reason causing leptin resistance in BBS, that it is underlying mechanism of development of  obesity in BBS. He has published over 70 peer-reviewed research articles in Journals including Cell Metabolism, Circulation Research, Hypertension, Kidney International, POLS genetics, et al. He actively services as Editorial board member of BOAJ Gynecology and Journal of Pharmacology Research & Therapeutics.


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