Mr. Nitin Yadav

ICGEB, New Delhi, India

Poster Presentation

Expertise: Biopharma and Bio technology

Bio:

Mr. Nitin Yadav, working as a Senior Research Fellow at International Centre for Genetic Engineering and Biotechnology · Mammalian Biology: Malaria. He finished his Master of Pharmacy (Pharmaceutics). And his research group has been working on conformationally restricted, designed peptides for many years. More recently, we have been interested in short, self-assembling peptides that may form stable nanostructures and explore their potential in various biomedical applications like drug delivery and tissue engineering. Working with chemically modified, short peptides we have shown their remarkable ability to form self-assembled nanostructures including nanoparticles, nanotubes and hydrogels for different applications.

Presentation :

Title : Instantaneous self-assembly of an ultrashort conformationally restrictedpeptide into highly stable & biocompatible hydrogel for drug delivery and tissue engineering

Abstract :

Self-assembling peptides serves as an attractive candidate for the development of various nanostructures including hydrogels with well-controlled biological, mechanical and material properties. Peptide based hydrogels offer several advantages such as their easy synthesis,characterization and decoration, biodegradability and most importantly their very high biocompatibility. Recent findings that relatively short peptides (di-, tri- and tetra-peptides) can readily self-assemble into ordered nanostructures including hydrogels, have made this area of research very active and exciting.Hydrogels based on peptidescontaining non protein amino acids are being considered as an excellent platform for various biomedical applications because of their inherent biocompatibility and additional proteolytic stability. Here we describe instantaneous selfassembly of a conformationally restricted dipeptide, containing an unnatural amino acid residue at their C-terminal, Leucine-a,ß-dehydrophenylalanine, into a highly stable and mechanically strong hydrogel, under mild physiological aqueous conditions. The hydrogel successfully entrapped several hydrophobic as well as hydrophilic drug molecules and released them in a controlled manner. The gel was highly biocompatible and injectable. Hydrogel injected with an anticancer drug into a tumor xenograft mice model efficiently controlled tumor growth. Additionally, hydrogel supported three dimensional culture of cells in vitro. Application of hydrogel on critical bone defect in rabbit showed significant recovery of bone tissue with reduction in inflammation at the defect site. These characteristics make this modified dipeptide hydrogel an attractive candidate for further development as a platform for drug delivery and tissue engineering.

Related Journals & Conferences :

International Biotechnology and Pharmaceutical Industry Forum